CBEMS 132 Bioseparation Processes (2012-2013)

CBEMS 132 Bioseparation Processes

(Not required for any major. Selected Elective for ChE.)
Catalog Data:

CBEMS 132 Bioseparation Processes (Credit Units: 3) Recovery and purification of biologically produced proteins and chemicals. Basic principles and engineering design of various separation processes including chromatography, electrophoresis, extraction, crystallization, and membrane separation. Prerequisite: CBEMS40A-B or CBEMS45A-B-C; CBEMS120A or CBEMS125A. (Design units: 1)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0195123401.

Recommended Textbook:

Belter, P.A., Cussler, E.L., and Hu, W. Bioseparation, Downstream Processing for Biotechnology, John Wiley & Sons, 1988.

Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Apply chemical engineering fundamentals such as material and energy balance, thermodynamics to design separation processes specific to biologically produced products.

2. Select and design separation processes to isolate, recover and purify valuable products produced from biological processes.

3. Design and analyze filtration processes, centrifugation processes, cell disruption processes, extraction processes, adsorption processes, chromatographic separation processes, precipitation and crystallization processes, ultrafiltration processes, electrophoresis processes.

Prerequisites by Topic

Material and energy balance, momentum transfer, thermodynamics

Lecture Topics:
  • Review of thermodynamics
  • Classification of separation processes
  • Crystallization and Precipitation
  • Adsorption and Chromatography
  • Electrophoretic Separation
  • Membrane Separation
  • Sequencing Separations
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:

Matlab or Polymath

Laboratory Projects:


Professional Component

This course is designed to contribute to the student’s knowledge of biology and chemical engineering topics and separation process design.

Design Content Description

Lectures and homework on synthesis of separation sequence

Lectures: 100%
Laboratory Portion: 0%
Grading Criteria:
  • Homework 20 %
  • Exam I 40 %
  • Exam II 40 % (during the final exam period)
  • Total 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 3.0 credit units

Engineering Science: 2.0 credit units

Engineering Design: 1.0 credit units

July 9, 2012
Senate Approved:
January 24, 2008
Approved Effective:
2008 Fall Qtr