CBEMS 126 Biomedical Photonics (2012-2013)

CBEMS 126 Biomedical Photonics

(Not required for any major.)
Catalog Data:

CBEMS 126 Biomedical Photonics (Credit Units: 3) Biophysical principles governing the interaction of laser radiation with biological materials, cells, and tissues. Utilization of these principles in several biomedical therapeutic and diagnostic applications is also covered and discussed in detail. Prerequisite: CBEMS120A-B or CBEMS125A-B-C; or consent of instructor. Concurrent with CBEMS 226. (Design units: 0)

Required Textbook:
Recommended Textbook:

A.J. Welch and M.J.C. van Gemert, editors, Optical-Thermal Response of Laser-Irradiated Tissue, Plenum, 1995.

Vasan Venugopalan
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Understand the electronic and vibrational molecular transitions of bio-molecules that govern optical absorption properties of biological tissues.

2. Understand the material properties that govern the optical cattering within biological tissues.

3. Understand the principles that govern radiative transport in absorbing and scattering tissues.

4. Understand the principles governing laser-induced thermal processes in tissue.

5. Determine the magnitude of thermo-elastic stresses generated by pulsed laser irradiation.

6. Determine if thermal or mechanical confinement is established in a pulsed laser application.

7. Understand the layout of a Jablonski diagram and the radiative and non-radiative processes that it depticts.

8. Be exposed to photochemistry and photodymanic therapy.

9. Be exposed to the governing principles of optical coherence and multi-photon microscopy techniques.

10. Be familiar with the capabilities of highly focused laser beams for cellular microsurgery and micromanipulation.

Prerequisites by Topic

Fluid Mechanics, Heat and Mass Transfer

Lecture Topics:
  • Introduction/Overview
  • Optical Properties of Biological Tissues
  • Radiative Transport within the Turbid Media
  • Photothermal Phenomena
  • Photomechanical Phenomena
  • Photochemical Phenomena
  • Optical Coherence Tomography
  • Two-photon and Confocal Microscopy
  • Optical Tweezers and Scissors
  • Photodynamic Therapy
  • Student Paper Presentations
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:


Laboratory Projects:


Professional Component

This course is designed to contribute to the students’ knowledge of engineering topics that are related to use of biomedical optics and photonic systems for biomedical diagnostic systems. Basic concepts covered in theis course have application domains ranging from single molecule detection, optical sensors, bioMEMS, biomedical microscopy, coherent optical imaging and diffuse optical/functional imaging.

Design Content Description


Laboratory Portion:
Grading Criteria:
  • Term project: 45%
  • Midterm exam: 45%
  • Homework & class discussion: 10%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 3.0 credit units

Engineering Science: 3.0 credit units

Engineering Design: 0.0 credit units

February 6, 2012
Senate Approved:
January 24, 2008
Approved Effective:
2008 Fall Qtr