CBEMS 108 Biopharmaceutics & Nanomedicine (2015-2016)

CBEMS 108 Biopharmaceutics & Nanomedicine

(Not required for any major.)
Catalog Data:

CBEMS 108 Biopharmaceutics & Nanomedicine (Credit Units: 4) Introduces theories and tools of new drug formulations. Particularly new novel therapeutics based on biological materials, pathological characteristics utilized to achieve the maximum efficacy and specificity, and drug delivery systems based on emerging nanotechnology are extensively discussed. Prerequisite: Pharmaceutical Sciences 170B or consent of instructor. Same as PHRMSCI 174. (Design units: 0)

Required Textbook:
None
Recommended Textbook:
None
References:

Articles from scientific journals in drug discovery, medicinal chemistry, drug delivery, and clinical sciences: Science, Nature, Pharmaceutical Research, Advanced Drug Delivery Reviews, journal of Controlled Release, Bioconjugate Chemistry, Medicinal Chemistry, etc.

Coordinator:
Young Jik Kwon
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Challenges and limits in pharmaceutical sciences using traditional drugs

2. Advantages of using biological materials as therapeutics

3. How to maximize therapeutic efficacy by using delivery carriers

4. Impact of multi-disciplinary technologies on pharmaceutical sciences

5. Current race for more efficient, safer, more economic therapeutics for major threats to human health.

Prerequisites by Topic

Biochemistry, cell biology/immunology, physiology, materials chemistry, nanotechnology/colloid science.

Lecture Topics:
  1. Introduction to pharmacology and pharmacokinetics (biodistribution, biocompatibility)

  2. Genetic therapeutics (DNA, siRNA)

  3. Protein-based therapeutics (vaccines, recombinant proteins, therapeutic antibodies)

  4. Cell-based therapy (somatic and stem cells)

  5. Pathological targets (pH, temperature, enzymatic activity)

  6. Drug delivery systems (polymer & lipid-based, biological)

  7. Diagnostic therapeutics (modalities for in vivo imaging)

  8. Nanomedicine (targeted delivery vehicles)

  9. Emerging technologies for biopharmaceutics

Class Schedule:

Meets for 3 hours of lecture and 1 hour of discussion each week for 10 weeks.

Computer Usage:

none

Laboratory Projects:
Professional Component
Design Content Description
Approach:
Lectures:
Laboratory Portion:
Grading Criteria:

25% Assignments

25% Midterm exam

15% Participation and presentation during discussion, assessed by TAs

35% Final exam

100% Total

Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

Prepared:
August 6, 2014
Senate Approved:
June 6, 2013
Approved Effective:
2013 Fall Qtr