BME 225 Tissue and Organ Biophotonics (2017-2018)

BME 225 Tissue and Organ Biophotonics

(Not required for any major.)
Catalog Data:

BME 225 Tissue and Organ Biophotonics (Credit Units: 4) Principles underlying the application and photonic technologies to tissues, organs, organisms. Sample technologies include Optical Coherence Tomography, Optical Speckle Imaging, Optoacoustic Imaging, Wide-Field Spectroscopic Imaging, Diffuse Optical Spectroscopy. Addressing the use of these technologies to detect/monitor disease and physiological processes. Graduate students only. . (Design units: 0)

Required Textbook:
Recommended Textbook:


Vasan Venugopalan
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:
Prerequisites by Topic


Lecture Topics:
  • Lecture 1-1: Light-Tissue Interactions on Mesoscopic/Macroscopic Scales
  • Lecture 1-2: Optical Properties and Tissue Morphology and Composition
  • Lecture 2-1: Biology and Treatment of Vascular Lesions
  • Lecture 2-2: Speckle Imaging of Biological Flow
  • Lecture 3-1: Laser Speckle Imaging Technology Fundamentals
  • Lecture 3-2: Student Reports/Presentations
  • Lecture 4-1: Biology and Treatment of Ischemic Stroke
  • Lecture 4-2: Tissue Structure and Flow Imaging Using Optical Coherent Tomography (OCT)
  • Lecture 5-1: OCT Technology Fundamentals
  • Lecture 5-2: Student Reports and Presentations
  • Lecture 6-1: Immunology and Cancer
  • Lecture 6-2: Development of Bioluminscence Reporters to Probe Cell-Cell Interactions
  • Lecture 7-1: Technology Fundamentals for Bioluminescence Imaging
  • Lecture 7-2: Student Reports and Presentations
  • Lecture 8-1: Hemodynamics in Brain and Muscle
  • Lecture 8-2: Diffuse Optical Spectroscopy and Imaging (DOSI)
  • Lecture 9-1: DOSI Technology Fundamentals
  • Lecture 9-2: Student Reports and Presentations
  • Lecture 10-1: Integration of Diffuse Optics and Optoacoustic Imaging
  • Lecture 10-2: Course Wrap-Up
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:

None beyond routine data analysis and image visualization/processing.

Laboratory Projects:


Professional Component


Design Content Description
Laboratory Portion:
Grading Criteria:

Problem Based Learning Projects: 100%

Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

February 22, 2017
Senate Approved:
January 6, 2016
Approved Effective:
2016 Fall Qtr