# BME 215 Linking Modeling and Experiments in Bioengineering (2014-2015)

#### BME 215 Linking Modeling and Experiments in Bioengineering

**BME 215 Linking Modeling and Experiments in Bioengineering (Credit Units: 4)** Overview of modeling based on experimental techniques in bioengineering. Construct and evaluate models of varying complexity and to relate them to experimental data. Prerequisite: BME 220 and BME 221. Graduate students only. (Design units: 0)

1. Identify the proper fit-validate loop for modeling biological systems.

2. Analyze experimental techniques from a modeling point of view.

3. Understand the limitations of both the experimental platforms and models.

4. Properly interpret results and consequences of models in published papers.

5. Construct and adjust simple models of biological constructs.

Math or engineering class on differential-equations and linear algebra. Basic physiology (BME 120 and 121 or BME 220 and 221).

- Overview of basic modeling rules
- Overview of basic programming necessary for the class
- Experimental Platform: Patch Clamping
- Modeling of ion channels in cardiomyocytes
- Experimental Platform: Microcontact Printing
- Modeling of myofibrillogenesis
- Applications of models in experimental design and tool building for industry
- Overview of other organ systems/tissues that students might with to model for their projects (kidneys, lungs, etc.)

Meets for 3 hours of lecture each week for 10 weeks.

MatLab.

None.

- Modeling Project: 20%
- Homework: 70%
- Discussion: 10%
- Total: 100%

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units