BME 213 Systems Cell and Developmental Biology (2014-2015)

BME 213 Systems Cell and Developmental Biology

(Not required for any major. Elective for BME-G.)
Catalog Data:

BME 213 Systems Cell and Developmental Biology (Credit Units: 4) Introduces concepts needed to understand cell and developmental biology at the systems level, i.e. how the parts (molecules) work together to create a complex output. Emphasis on using mathematical/computational modeling to expand/modify insights provided by intuition. Graduate students only. Same as DEV BIO 232. (Design units: 0)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0815341055.

. Edition, , 1969, ISBN-13 978-1584886426.

Recommended Textbook:
None
References:

Additional readings as assigned by professor

Coordinator:
Lee Bardwell and Arthur D. Lander
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Be able to describe concepts of cell and developmental biology.

2. Be able to describe how parts (molecules) work together to create a complex output.

3. Be able to demonstrate mathematical/computational modeling to expand/modify insights provided by intuition.

4. Work in multi-disciplinary teams to model biological systems.

Prerequisites by Topic

Graduate standing or permission of the instructor

Lecture Topics:
  • Module I Signaling Networks: Proteins and Enzymes, Signaling, Signaling Cascades and Networks
  • Module II Regulatory Logic: Gene Regulation, The Logic of Gene Regulation, Cellular Design Principles
  • Module III The Cell Cycle: The Cell Cycle, Oscillating Systems
  • Module IV Sensing & Responding: G-proteins and sensing, G-proteins and cell polarity, Principles of chemotaxis
  • Module V Cytoskeleton & Tranport: Microtubles & Actin, Motors, Coordination
  • Module VI Developmental Morphogenesis: Principles of developmental biology, Strategies for creating pattern, Creating and interpreting morphogen gradients, Robustness, noise suppression, and coordination, Integrating growth, movement and patterning, Developmental gene regulatory networks
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:

The homework will emphasize using Mathematica software to construct and analyze simple models of signaling pathways, gene regulatory networks, the cell cycle, developmental patterning systems, etc.

Laboratory Projects:

None.

Professional Component

None.

Design Content Description
Approach:
Lectures:
Laboratory Portion:
Grading Criteria:
  • Homework: Four Assignments 40%
  • Final: Take Home Exam 60%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

Prepared:
April 15, 2014
Senate Approved:
May 8, 2013
Approved Effective:
2013 Winter Qtr