BME 210 Molecular and Cellular Engineering (2015-2016)

BME 210 Molecular and Cellular Engineering

(Not required for any major.)
Catalog Data:

BME 210 Molecular and Cellular Engineering (Credit Units: 4) Engineering of physiological function at the genetic, cellular, and tissues scales. Topics include cloning and genetic engineering, extracellular matrix biomaterials, principles of regenerative and tissue engineering, and experimental design. Graduate students only. (Design units: 0)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0123708694.

Recommended Textbook:
None
References:
  • Alberts, et. al., Molecular Biology of the Cell, 5th edition, 2007, Garland Science, ISBN# 978-0-8153-4105-5
  • Patrick et. al., Frontiers in Tissue Engineering, 1st edition, 1998, Elsevier Science, ISBN# 0-08-042689-1
  • Lanza, Vacanti, Langer, Principles of Tissue Engineering, 3rd edition, 2007, Elsevier Academic Press, ISBN# 13-978-0-12-370615-7
  • B. Ratner, A. Hoffman, F. Schoen, J. Lemons, Biomaterials Science: An Introduction to Materials in Medicine, 2nd edition, 2004, Elsevier Academic Press, ISBN# 0-12-582463-7
  • Bernhard O. Palsson and Sangeeta N. Bhatia, Tissue Engineering,, 1st edition, 2004, Pearson Prentice Hall, ISBN-10: 0130416967
  • Mark W. Saltzman, Tissue Engineering: Engineering Principles for the Design of Replacement Organs and Tissues, 1st edition, Oxford University Press, 2004, ISBN# 0-19-514130-X
  • Guilak, Butler, Goldstein, and Moone, Functional Tissue Engineering, 1st edition, Springer-Verlag, 2003, ISBN# 0-387-95553-4
Coordinator:
Elliot E. Hui
Relationship to Student Outcomes
This course relates to Student Outcomes: EAC a, EAC b, EAC d.
Course Learning Outcomes. Students will:

1. Demonstrate an in-depth knowledge of molecular biology and cell biology. (EAC a)

2. Design basic strategies for the genetic engineering of cellular function and for the engineering of functional tissue constructs. (EAC b)

3. Interpret and evaluate experimental data from primary literature and design well-controlled experimental molecular, cellular, and tissue scales. (EAC a, EAC b, EAC d)

Prerequisites by Topic

Molecular Biology (BME50A or equivalent). Cell Biology (BME50B or equivalent).

Lecture Topics:
  • Biological strategies for information storage and transfer
  • DNA sequencing, cloning, and synthesis
  • Tissue organization, morphogenesis, and remodeling
  • Sources of cells (including stem cells) and regulation of cell fate
  • Biomaterial scaffolds as synthetic ECM analogs
  • Immune Response to cells and biomaterials
  • Controlled release strategies
  • Cellular biomechanics and mechanotransduction
  • Mass transport and the need for vascularization
  • Principles of experimental design
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:

N/A

Laboratory Projects:

None.

Professional Component

None.

Design Content Description
Approach:

None.

Lectures:
Laboratory Portion:
Grading Criteria:
  • Homeworks: 20%
  • Midterm: 40%
  • Final: 40%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

Prepared:
August 6, 2014
Senate Approved:
April 25, 2014
Approved Effective:
2014 Fall Qtr