BME 210 Cell and Tissue Engineering (2013-2014)

BME 210 Cell and Tissue Engineering

(Not required for any major.)
Catalog Data:

BME 210 Cell and Tissue Engineering (Credit Units: 4) A biochemical, biophysical, and molecular view of cell biology. Topics include the biochemistry and biophysical properties of cells, the extracellular matrix, biological signal transduction, and principles of engineering new tissues. Graduate students only. (Design units: 0)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0123708694.

Recommended Textbook:
  • Alberts, et. al., Molecular Biology of the Cell, 5th edition, 2007, Garland Science, ISBN# 978-0-8153-4105-5
  • Patrick et. al., Frontiers in Tissue Engineering, 1st edition, 1998, Elsevier Science, ISBN# 0-08-042689-1
  • Lanza, Vacanti, Langer, Principles of Tissue Engineering, 3rd edition, 2007, Elsevier Academic Press, ISBN# 13-978-0-12-370615-7
  • B. Ratner, A. Hoffman, F. Schoen, J. Lemons, Biomaterials Science: An Introduction to Materials in Medicine, 2nd edition, 2004, Elsevier Academic Press, ISBN# 0-12-582463-7
  • Bernhard O. Palsson and Sangeeta N. Bhatia, Tissue Engineering,, 1st edition, 2004, Pearson Prentice Hall, ISBN-10: 0130416967
  • Mark W. Saltzman, Tissue Engineering: Engineering Principles for the Design of Replacement Organs and Tissues, 1st edition, Oxford University Press, 2004, ISBN# 0-19-514130-X
  • Guilak, Butler, Goldstein, and Moone, Functional Tissue Engineering, 1st edition, Springer-Verlag, 2003, ISBN# 0-387-95553-4
Elliot E. Hui
Relationship to Student Outcomes
This course relates to Student Outcomes: EAC a, EAC b, EAC d.
Course Learning Outcomes. Students will:

1. Demonstrate an in-depth knowledge of molecular biology and cell biology. (EAC a)

2. Design basic strategies for the genetic engineering of cellular function and for the engineering of functional tissue constructs. (EAC b)

3. Interpret and evaluate experimental data from primary literature and design well-controlled experimental molecular, cellular, and tissue scales. (EAC a, EAC b, EAC d)

Prerequisites by Topic

Molecular Biology (BME50A or equivalent). Cell Biology (BME50B or equivalent).

Lecture Topics:
  • Biological strategies for information storage and transfer
  • DNA sequencing, cloning, and synthesis
  • Tissue organization, morphogenesis, and remodeling
  • Sources of cells (including stem cells) and regulation of cell fate
  • Biomaterial scaffolds as synthetic ECM analogs
  • Immune Response to cells and biomaterials
  • Controlled release strategies
  • Cellular biomechanics and mechanotransduction
  • Mass transport and the need for vascularization
  • Principles of experimental design
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:


Laboratory Projects:


Professional Component


Design Content Description


Laboratory Portion:
Grading Criteria:
  • Homeworks: 20%
  • Midterm: 40%
  • Final: 40%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

July 11, 2013
Senate Approved:
May 30, 2013
Approved Effective:
2013 Fall Qtr