BME 210 Cell and Tissue Engineering (2012-2013)

BME 210 Cell and Tissue Engineering

(Not required for any major.)
Catalog Data:

BME 210 Cell and Tissue Engineering (Credit Units: 4) A biochemical, biophysical, and molecular view of cell biology. Topics include the biochemistry and biophysical properties of cells, the extracellular matrix, biological signal transduction, and principles of engineering new tissues. Graduate only. (Design units: 0)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0123708694.

Recommended Textbook:
None
References:
  • Alberts, et. al., Molecular Biology of the Cell, 5th edition, 2007, Garland Science, ISBN# 978-0-8153-4105-5
  • Patrick et. al., Frontiers in Tissue Engineering, 1st edition, 1998, Elsevier Science, ISBN# 0-08-042689-1
  • Lanza, Vacanti, Langer, Principles of Tissue Engineering, 3rd edition, 2007, Elsevier Academic Press, ISBN# 13-978-0-12-370615-7
  • B. Ratner, A. Hoffman, F. Schoen, J. Lemons, Biomaterials Science: An Introduction to Materials in Medicine, 2nd edition, 2004, Elsevier Academic Press, ISBN# 0-12-582463-7
  • Bernhard O. Palsson and Sangeeta N. Bhatia, Tissue Engineering,, 1st edition, 2004, Pearson Prentice Hall, ISBN-10: 0130416967
  • Mark W. Saltzman, Tissue Engineering: Engineering Principles for the Design of Replacement Organs and Tissues, 1st edition, Oxford University Press, 2004, ISBN# 0-19-514130-X
  • Guilak, Butler, Goldstein, and Moone, Functional Tissue Engineering, 1st edition, Springer-Verlag, 2003, ISBN# 0-387-95553-4
Coordinator:
Elliot E. Hui
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Apply engineering principles to analyze and predict specific cell physiological behaviors.

2. Integrate fundamental knowledge from cell and molecular biology, physiology, and biomechanics to comprehend recently published approaches to tissue engineering.

3. Quantitatively analyze the function and structure of native tissues, and to rationally design effective strategies for engineered tissues based on these analyses.

4. Understand and apply the designs of biomaterial scaffolds based on naturally derived materials or biodegradable synthetic polymers.

5. Synthesize novel ideas and strategies related to tissue engineering in an effort to improve current approaches.

Prerequisites by Topic

None.

Lecture Topics:
  • Brief History of Tissue Engineering
  • Review of Cell Structure and Function (Focus on Cytoskeleton, Receptors, and Signaling)
  • Tissue organization, morphogenesis, and remodeling
  • Sources of cells (including stem cells) and regulation of cell fate
  • Extracellular Matrix (ECM) and Its Role in Tissue Development and Function
  • Biomaterial Scaffolds as Synthetic ECM Analogs
  • Cell and Tissue Mechanics -- Relevance in Tissue Engineering and Pathology
  • Cell Migration and Invasion in Tissue Engineering and Cancer
  • Biomechanical Considerations and Mechanotransduction in Tissue Engineering
  • Wound Healing and Immunology/Biocompatibility
  • Mass Transport and the Need for Vascularization
  • Therapeutic Angiogenesis, Drug and Gene Delivery (including Targeted and Controlled Release Strategies)
  • Clinical Successes in Tissue Engineering
Class Schedule:

Meets for 4 hours of lecture each week for 10 weeks.

Computer Usage:

Word processing and PowerPoint

Laboratory Projects:

None.

Professional Component

None.

Design Content Description
Approach:

None.

Lectures:
Laboratory Portion:
Grading Criteria:
  • White paper: 20%
  • Group presentations: 20%
  • Midterm: 30%
  • Final: 30%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

Prepared:
January 14, 2013
Senate Approved:
November 16, 2007
Approved Effective:
2008 Fall Qtr