BME 160 Tissue Engineering (2016-2017)

BME 160 Tissue Engineering

(Required for BME and BMEP. Selected Elective for ChE.)
Catalog Data:

BME 160 Tissue Engineering (Credit Units: 4) Quantitative analysis of cell and tissue functions. Emerging developments in stem cell technology, biodegradable scaffolds, growth factors, and others important in developing clinical products. Applications to bioengineering. Prerequisite: (BME 50B or BioSci 99) and BME 111, BME 121, BME 150. Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment. (Design units: 1)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0123708694.

Recommended Textbook:
. Edition, , 1969, ISBN-13 978-0130416964.

Anna Grosberg
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Apply cell biology to engineering problems in regenerative medicine.

2. Apply material science to the design of tissue-engineered constructs.

3. Understand the ethical responsibilities of engineers.

4. Understand the ethical, economic, and societal implications of tissue engineering.

Prerequisites by Topic

Cell and molecular engineering. Quantitative physiology: sensory motor systems.

Lecture Topics:
  • Overview of tissue engineering.
  • Tissue organization, morphogenesis, and remodeling.
  • Sources of cells and cell culture.
  • Extracellular signaling/regulation of cell fate.
  • Biomaterial scaffold design.
  • Biocompatibility and immunology.
  • Biomechanics and mechanotransduction.
  • Mass transport and strategies for vascularization.
  • Growth factor and gene delivery
  • Case studies in tissue engineering.
  • Discussions on relevant literature papers.
  • Student presentations of mock grant proposals.
Class Schedule:

Meets for 3 hours of lecture and 1 hour of discussion each week for 10 weeks.

Computer Usage:

MS Word usage required for preparation of final project

Laboratory Projects:


Professional Component

Contributes toward the Biomedical Engineering Topics and Major Design experience.

Design Content Description

Students will organize into groups of 3-4 students and prepare a mock grant proposal (typical NIH or NSF format) designed to engineer a specific tissue in the human body. The engineered tissue must be clinically relevant (i.e., provide a potential solution to a specific disease or condition), and the proposal should clearly build on the existing literature. The design MUST include some aspect of the course, such as the use of a biodegradable scaffold, the design of a bioreactor capable of applying mechanical loads to an engineered tissue, growth factor delivery, biomechanical analysis of the engineered tissue, etc. Grant writing guidelines will be provided at a later date. In addition to a written proposal (approximately 15-20 pages), teams will prepare 15-20 minute presentations of their design to be presented in front of their peers during the last week of the quarter. (75%) Strategies for engineering functional tissues based on rational design and biomimetics are emphasized throughout the course, including topics on synthetic ECM analogs, mass transport/vascularization, and growth factor and gene delivery. (25%)

  • Design content:
  • Homework (Final Project): 85%
  • Exams: 10%
  • Lectures: 5%
Lectures: 5%
Laboratory Portion: 0%
Grading Criteria:
  • Final Project: 10%
  • Exams (3 Midterm Exams and 2 Part Final Exam): 90%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 4.0 credit units

Engineering Science: 2.0 credit units

Engineering Design: 2.0 credit units

July 12, 2016
Senate Approved:
March 11, 2014
Approved Effective:
2014 Fall Qtr