BME 160 Tissue Engineering (2015-2016)

BME 160 Tissue Engineering

(Required for BME and BMEP. Selected Elective for ChE.)
Catalog Data:

BME 160 Tissue Engineering (Credit Units: 4) Quantitative analysis of cell and tissue functions. Emerging developments in stem cell technology, biodegradable scaffolds, growth factors, and others important in developing clinical products. Applications to bioengineering. Prerequisite: (BME 50B or BioSci 99) and BME 111, BME 121, BME 150. Biomedical Engineering and Biomedical Engineering: Premedical majors have first consideration for enrollment. (Design units: 1)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0123708694.

Recommended Textbook:
. Edition, , 1969, ISBN-13 978-0130416964.

Anna Grosberg
Relationship to Student Outcomes
This course relates to Student Outcomes: EAC a, EAC f, EAC j.
Course Learning Outcomes. Students will:

1. Apply cell biology to engineering problems in regenerative medicine. (EAC a)

2. Apply material science to the design of tissue-engineered constructs. (EAC a)

3. Understand the ethical responsibilities of engineers. (EAC f)

4. Understand the ethical, economic, and societal implications of tissue engineering. (EAC f, EAC j)

Prerequisites by Topic

Cell and molecular engineering. Quantitative physiology: sensory motor systems.

Lecture Topics:
  • Overview of tissue engineering.
  • Tissue organization, morphogenesis, and remodeling.
  • Sources of cells and cell culture.
  • Extracellular signaling/regulation of cell fate.
  • Biomaterial scaffold design.
  • Biocompatibility and immunology.
  • Biomechanics and mechanotransduction.
  • Mass transport and strategies for vascularization.
  • Growth factor and gene delivery
  • Case studies in tissue engineering.
  • Discussions on relevant literature papers.
  • Student presentations of mock grant proposals.
Class Schedule:

Meets for 3 hours of lecture and 1 hour of discussion each week for 10 weeks.

Computer Usage:

MS Word usage required for preparation of final project

Laboratory Projects:


Professional Component

Contributes toward the Biomedical Engineering Topics and Major Design experience.

Design Content Description

Students will organize into groups of 3-4 students and prepare a mock grant proposal (typical NIH or NSF format) designed to engineer a specific tissue in the human body. The engineered tissue must be clinically relevant (i.e., provide a potential solution to a specific disease or condition), and the proposal should clearly build on the existing literature. The design MUST include some aspect of the course, such as the use of a biodegradable scaffold, the design of a bioreactor capable of applying mechanical loads to an engineered tissue, growth factor delivery, biomechanical analysis of the engineered tissue, etc. Grant writing guidelines will be provided at a later date. In addition to a written proposal (approximately 15-20 pages), teams will prepare 15-20 minute presentations of their design to be presented in front of their peers during the last week of the quarter. (75%) Strategies for engineering functional tissues based on rational design and biomimetics are emphasized throughout the course, including topics on synthetic ECM analogs, mass transport/vascularization, and growth factor and gene delivery. (25%)

  • Design content:
  • Homework (Final Project): 85%
  • Exams: 10%
  • Lectures: 5%
Lectures: 5%
Laboratory Portion: 0%
Grading Criteria:
  • Final Project: 10%
  • Exams (3 Midterm Exams and 2 Part Final Exam): 90%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 4.0 credit units

Engineering Science: 2.0 credit units

Engineering Design: 2.0 credit units

August 6, 2014
Senate Approved:
March 11, 2014
Approved Effective:
2014 Fall Qtr