BME 160 Tissue Engineering (2012-2013)

BME 160 Tissue Engineering

(Required for BME and BMEP. Selected Elective for ChE.)
Catalog Data:

BME 160 Tissue Engineering (Credit Units: 4) Quantitative analysis of cell and tissue functions. Emerging developments in stem cell technology, biodegradable scaffolds, growth factors, and others important in developing clinical products. Applications to bioengineering design. Prerequisite: BME50A-B, BME 121. (Design units: 2)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0123708694.

Recommended Textbook:
. Edition, , 1969, ISBN-13 978-0130416964.

Anna Grosberg
Relationship to Student Outcomes
This course relates to Student Outcomes: EAC a, EAC f, EAC j.
Course Learning Outcomes. Students will:

1. Apply cell biology to engineering problems in regenerative medicine. (EAC a)

2. Apply material science to the design of tissue-engineered constructs. (EAC a)

3. Understand the ethical responsibilities of engineers. (EAC f)

4. Understand the ethical, economic, and societal implications of tissue engineering. (EAC f, EAC j)

Prerequisites by Topic

Cell and molecular engineering. Quantitative physiology: sensory motor systems. Biomaterials.

Lecture Topics:
  • Tissue Engineering and academic integrity, morphogenesis, tissue homeostasis (week 1)
  • Stem cells, ethics and stem cells, extracellular matrix (week 2)
  • Tissue organization on multiple scales, immunostaining, microscopy (week 3)
  • Force measurements, electrophysiology (week 4)
  • High-throughput biological data, cell sources (week 5)
  • Stem cell sources, cell nutrition (week 6)
  • Scafold design, engineering cell organization, cryobiology (week 7)
  • Tissue engineering experimental design, skin tissue engineering (week 8)
  • CNS tissue engineering, organ systems tissue engineering, history of ethics and current laws in tissue engineering (week 9)
  • Design Projects (week 10)
Class Schedule:

Meets for 3 hours of lecture and 1 hour of discussion each week for 10 weeks.

Computer Usage:

Access to ImageJ (free software provided by NIH).

Laboratory Projects:


Professional Component

Contribues toward the Biomedical Engineering and Biomedical Engineering: Premedical topics courses.

Design Content Description

Students will organize into groups of 5-6, and will design a device or experiment to meet a specific technological challenge or to test a specific scientific hypothesis. During the quarter students will be prepared for the final project by being challenged to solve small design problems on their exams, with example of such problems shown in lecture. Once the projects are completed, students will give presentations (10-15 min) detailing their designs in front of their peers. The final project grade will be divided into two parts. In the first part, the students will be evaluated by the instructor and teaching assistants based on the approach taken and clarity of technical detail. The second part of the grade will be based on inter-team evaluations, to ensure equal participation of each student.

  • Design content:
  • Homework (Final Project): 85%
  • Exams: 10%
  • Lectures: 5%
Lectures: 5%
Laboratory Portion: 0%
Grading Criteria:
  • Final Project: 10%
  • Exams (3 Midterm Exams and 2 Part Exam): 90%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 2.0 credit units

Computing: 0.0 credit units

Engineering Topics: 2.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 2.0 credit units

October 25, 2012
Senate Approved:
March 5, 2002
Approved Effective:
2002 Fall Qtr