BME 147 Microfluidics and Lab-on-a-Chip (2013-2014)

BME 147 Microfluidics and Lab-on-a-Chip

(Not required for any major. Selected Elective for BME.)
Catalog Data:

BME 147 Microfluidics and Lab-on-a-Chip (Credit Units: 4) Introduction to principles of microfluidics; LOC (Lab-on-a-Chip) device design, fabrication, operation principles for microscale flow transport, bimolecular manipulation/separation/detection, sample preparation; integrated microfluidic technologies for micro total analysis systems (microTAS) and bioassays. Applications introduced: clinical medicine, health monitoring, biotechnology, biodetection. Prerequisite: BME111, and EECS179. Biomedical Engineering majors have first consideration for enrollment. Concurrent with BME 247. (Design units: 1)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0199235094.

Recommended Textbook:

Class notes

Abraham Lee
Relationship to Student Outcomes
This course relates to Student Outcomes: EAC a, EAC e, EAC g, EAC k.
Course Learning Outcomes. Students will:

1. Understand the fundamentals of microfluidics technology and apply it towards the manipulation and analysis of biological cells and biomolecules on biochips. (EAC a)

2. Be able to design a microfluidic LOC system to solve a real-world diagnostics problem. (EAC e)

3. Be able to compare and critique existing microfluidic systems for various biomolecular assays and develop the knowledge base in state-of-the-art microfluidic LOC devices. (EAC g)

4. Be able to describe the steps in constructing a microsystem (design, fabrication) for for biological sample analysis and disease management. (EAC k)

Prerequisites by Topic

Microfluidics device design tools, fabrication, packaging, surface treatment and testing techniques; common fabrication materials, biocompatibility, and familiarity with biomolecules and cells.

Lecture Topics:
  • Introduction: scaling of fluids at the microscale and its implications on devices
  • Review of microfabrication background
  • Physics and modeling of microfluidic systems
  • Microfluidic transport
  • Microfluidic sample preparation
  • Microfluidic sample detection
  • Two-phase microfluidics and its applications
Class Schedule:

Meets for 3 hours of lecture and 1 hour of discussion each week for 10 weeks.

Computer Usage:

Students will use word processors and drawing programs to do homework assignments.

Laboratory Projects:


Professional Component

Contributes toward the Biomedical Engineering Topics and Major Design experience.

Design Content Description

Specific discussions on system and device designs (50%). Students will use learned skills to design systems and devices for lab-on-chip systems (50%).

Lectures: 100%
Laboratory Portion: 0%
Grading Criteria:
  • Homework: 30%
  • Midterm: 30%
  • Final: 40%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 4.0 credit units

Engineering Science: 3.0 credit units

Engineering Design: 1.0 credit units

June 28, 2013
Senate Approved:
March 19, 2013
Approved Effective:
2013 Fall Qtr