BME 146 Miniaturization in Biotechnology and Biological Science (2012-2013)

BME 146 Miniaturization in Biotechnology and Biological Science

(Not required for any major. Selected Elective for BME.)
Catalog Data:

BME 146 Miniaturization in Biotechnology and Biological Science (Credit Units: 4) Introduction of BIOMEMS to engineering and science students. Study of various sensing technique fundamentals. Introduction to various biosensors. Introduction to biological principles using examples; nanomachining and biomimetics. (Design units: 1)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0849308260.

Recommended Textbook:

Class notes

William C. Tang
Relationship to Student Outcomes
This course relates to Student Outcomes: EAC a, EAC e, EAC k.
Course Learning Outcomes. Students will:

1. Understand the principles of operation of essential instruments in biotechnology that can be miniaturized (EAC k)

2. Develop the techniques for designing, fabricating, and evaluating miniaturized biotechnology instruments (EAC e)

3. Apply the fundamental principles of molecular based sensing, gene chips, microfluidics, and self assembly of biological sensors (EAC a)

Prerequisites by Topic

Freshman level chemistry and physics

Lecture Topics:
  • Introduction: From MEMS to BioMEMS
  • Electrochemistry background (I and II)
  • Optics background and acoustics background
  • Other sensing principles
  • Ion selective electrodes
  • Gas sensors
  • Enzyme based sensors
  • Protein based sensors
  • Immunosensors (I and II)
  • DNA probes and arrays (I and II)
  • DNA amplification
  • Cells and liposomes
  • Fluidics compared
  • CD fluidics
  • Total analysis systems
  • Nanomachining (I and II)
  • Biomimetics
Class Schedule:

Meets for 3 hours of lecture and 1 hour of discussion each week for 10 weeks.

Computer Usage:

Students will use word processors and spreadsheets to do homework assignments.

Laboratory Projects:


Professional Component

Contributes toward the Biomedical Engineering Topics and Major Design experience.

Design Content Description

Specific discussions on system and device designs. (50%) Students will use learned skills to design systems and devices for biotechnology. (50%)

Lectures: 100%
Laboratory Portion: 0%
Grading Criteria:
  • Homework assignments: 30%
  • Midterm exam: 30%
  • Final exam: 40%
  • Total 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 4.0 credit units

Engineering Science: 3.0 credit units

Engineering Design: 1.0 credit units

April 4, 2012
Senate Approved:
May 27, 2008
Approved Effective:
2008 Fall Qtr