BME 136 Engineering Medical Optics (2017-2018)

BME 136 Engineering Medical Optics

(Not required for any major. Selected Elective for BME.)
Catalog Data:

BME 136 Engineering Medical Optics (Credit Units: 4) Principles of optics and photonics, integration of optical components into systems and devices, and analysis of physiologic signals obtained from Biophotonics measurements. Prerequisite: BME130, BME135. Biomedical Engineering majors have first consideration for enrollment. Concurrent with BME 251. (Design units: 3)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0805385663.

Recommended Textbook:
None
References:

Lectures and problem sets are available and downloadable from the course website. Handouts from the instructor.

Coordinator:
Bruce Tromberg
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. Demonstrate knowledge of the fundamentals of optics and how basic principles are used to design and optimize optical instruments used in medical diagnostics

2. Describe geometrical optics and its role in the design of microscopy instruments

3. Describe wave optics and its role in the design of instrumentation for optical coherence tomography

4. Describe basics of light matter interactions and its role in spectroscopy instruments

5. Explain principles of diffuse optics and its role in the development of photon migration and photothermal techniques for subsurface tissue imaging

Prerequisites by Topic
  • Electromagnetic fields and solutions of problems in engineering applications.
  • Maxwell’s equations and plane wave propagation.
Lecture Topics:
  • Introduction and overview of biomedical optics
  • Principles of geometrical optics, lenses, apertures, ray diagrams
  • Principles of geometrical optics, fibers and waveguides
  • Integration of geometrical optics into Microscopy systems
  • Applications of microscopy systems and laser scanning microscopies
  • Laser scanning microscopy; Principles of waves, interference, coherence
  • Principles of polarization and Doppler
  • Integration of wave concepts into the design of optical coherence tomography (OCT) systems
  • Applications of OCT in biology and medicine
  • Basic light matter interactions: absorption, emission, scattering
  • Photonic devices- sources: lasers, LEDs, SLDs
  • Photonic devices- detectors: performance theory; photomultipliers, photodiodes, array detectors; System integration: Spectroscopy
  • Applications of spectroscopy in biology and medicine
  • Physiological Optics: eye structure, performance
  • Physiological Optics: vision mechanisms, image formation and perception
  • Image processing: modulation transfer function, transformation methods
  • Imaging: applications of image analysis and processing in biology and medicine
Class Schedule:

Meets for 3 hours of lecture and 3 hours of laboratory each week for 10 weeks.

Computer Usage:

Simulation, modeling, and virtual instruments

Laboratory Projects:

Lab projects will complement lecture topics in microscopy, interferometry, spectroscopy, and diffuse optics.

Professional Component

Contributes toward the Biomedical Engineering Topics and Major Design experience.

Design Content Description
Approach:

Analyze and critique the design of an optical instrument that has been used to solve a fundamental problem or provide clinical information in one or more broad areas of biology and medicine, such as, cancer, heart disease, wound healing, or neuroscience, etc. Students will work in small groups or teams. They will analyze relevant published literature and course materials, and present the instrument design in a formal class presentation with detailed slides. The main elements that must be covered include: biological background, competing technologies, novelty of approach, integrated technology problem solving.

Lectures: 30%
Laboratory Portion: 70%
Grading Criteria:
  • Homework: 25%
  • Midterm: 12.5%
  • Group project: 25%
  • Lab: 25%
  • Final: 12.5%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

Prepared:
February 22, 2017
Senate Approved:
April 9, 2014
Approved Effective:
2014 Fall Qtr