BME 114 Genetic Engineering and Synthetic Biology (2016-2017)

BME 114 Genetic Engineering and Synthetic Biology

(Not required for any major.)
Catalog Data:

BME 114 Genetic Engineering and Synthetic Biology (Credit Units: 4) Exploring how biological functions can be engineered and synthesized from the DNA level up. Prerequisite: MATH 3D and BME 50A-B. Biomedical Engineering students have first consideration for enrollment. . (Design units: 0)

Required Textbook:
. Edition, , 1969, ISBN-13 978-0815341055.

. Edition, , 1969, ISBN-13 978-0465075706 .

Recommended Textbook:
  • Original research papers and reviews. These will all be available online through UCI's subscriptions to various scientific journals. You are responsible for downloading, printing, and reading these papers as necessary.
  • J Chris Andersons's cloning tutorial
Relationship to Student Outcomes
No student outcomes specified.
Course Learning Outcomes. Students will:

1. This course will teach advanced undergraduate students to graduate students in Biomedical Engineering the principles and fundamental methodologies behind Genetic Engineering and Synthetic Biology.

2. Define genetic engineering and synthetic biology problems.

3. Understand engineering principles at the level of genes to cellular networks.

4. Design cloning strategies for manipulating genes in vitro and in vivo.

5. Understand methods and techniques of genetic engineering and synthetic biology.

Prerequisites by Topic

Cell and Molecular Biology (BME 50A and BME 50B or equivalent), Calculus with some exposure to Differential Equations, Organic Chemistry (strongly recommended but not required).

Lecture Topics:
  • Molecules of life
  • DNA technologies
  • Cloning
  • Origin of life from a synthetic biology approach
  • Genetic code manipulation
  • Genome engineering
  • Synthetic biological circuits
Class Schedule:

Meets for 3 hours of lecture each week for 10 weeks.

Computer Usage:

Requires a laptop to run free software provided

Laboratory Projects:


Professional Component
Design Content Description
Laboratory Portion:
Grading Criteria:
  • Class participation (graded on in-class literature analysis and discussion sessions, and presentation): 25%
  • Homework: 15%
  • Midterm Exam: 25%
  • Final Exam: 35%
  • Total: 100%
Estimated ABET Category Content:

Mathematics and Basic Science: 0.0 credit units

Computing: 0.0 credit units

Engineering Topics: 0.0 credit units

Engineering Science: 0.0 credit units

Engineering Design: 0.0 credit units

July 12, 2016
Senate Approved:
May 15, 2014
Approved Effective:
2014 Fall Qtr